المنشورات
Master Thesis
During my master’s thesis, I investigated colorectal cancer heterogeneity using single-cell and spatial transcriptomics, uncovering cancer cell states like LGR5+ cancer stem cells, EMP1+ high-relapse cells, and proliferative states in distinct spatial niches. I also identified critical tumor-microenvironment interactions, including SPP1+ macrophages and FAP+ fibroblasts co-localizing near high-relapse cells, revealing a potential CCL15-CCR1 signaling circuit driving macrophage recruitment and tumor progression.
Harnessing STING signaling and natural killer cells overcomes PARP inhibitor resistance in homologous recombination deficient breast cancer
Pedretti, F., Abdalfttah, M., Pellegrino, B., Mateo-González, F., Martínez-Sanz, P., Herencia-Ropero, A., Òdena, A., Clavell-Revelles, P., Casali, G., Domenech, H., Monserrat, L., Papić, D., Mas Malavila, A., Pascual-Reguant, A., Eixarch, H., Guzmán, M., Rodríguez, O., Grueso, J., Simonetti, S., ...Serra, V.
Cancer Research (2025)
Community assesses differential cell communication using large multi-sample case-control scRNAseq datasets
Solovey, M., Celik, M. A., Salcher, F. R., Abdalfttah, M., Ismail, M., Scialdone, A., ... & Colome-Tatche, M.
Cell Reports, 2024
Multigene panel sequencing reveals cancer-specific and common somatic mutations in colorectal cancer patients: an Egyptian experience
Youssef, A. S. E. D., Abdalfttah, M, Lotfy, M. M., Nassar, A., Abouelhoda, M., Touny, A. O., ... & Zekri, A. R. N.
Current issues in molecular biology (2022)
In Silico Characterization of Toxin-Antitoxin Systems in Campylobacter Isolates Recovered from Food Sources and Sporadic Human Illness
Wadie, B., Abdalfttah, M, Yousef, A., Mouftah, S. F., Elhadidy, M., & Salem, T. Z
Genes (2021)